Ir-Catalyzed Synthesis of Substituted Tribenzosilepins by Dehydrogenative C-H/Si-H Coupling.
Takanori ShibataNinna UnoTomoya SasakiHideaki TakanoTatsuki SatoKyalo Stephen KanyivaPublished in: The Journal of organic chemistry (2018)
The Ir-catalyzed intramolecular reaction of 2',6'-diaryl-2-(hydrosilyl)biphenyls gave substituted tribenzosilepins by direct dehydrogenative C-H/Si-H coupling. This is the first example of catalytic construction of the tribenzosilepin skeleton. Enantiomerically pure tribenzosilepin was prepared by optical resolution using chiral HPLC, and its inversion barrier was calculated by measurement of rate of racemization using the Eyring kinetic equation under heating conditions.
Keyphrases
- room temperature
- ionic liquid
- molecular docking
- ms ms
- simultaneous determination
- mass spectrometry
- high performance liquid chromatography
- high speed
- single molecule
- solid phase extraction
- contrast enhanced
- capillary electrophoresis
- tandem mass spectrometry
- computed tomography
- molecular dynamics simulations
- crystal structure
- energy transfer