Potential-resolved electrochemiluminescence for simultaneous determination of multiplex bladder cancer markers.
Junke WangFenglian GuoJingjing ZhangJie ChaoPublished in: Chemical communications (Cambridge, England) (2024)
A novel ECL immunosensor was developed for simultaneous determination of multiplex bladder cancer markers. DNA tetrahedra act as capture probes, while Ru-MOF@AuNPs and AuAgNCs act as signal reporters, yielding well-separated signals reflecting NUMA1 and CFHR1 concentrations. This strategy offers a new platform for clinical immunoassays, enabling simultaneous multiplex tumor marker detection.
Keyphrases
- simultaneous determination
- real time pcr
- high throughput
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- high performance liquid chromatography
- ultra high performance liquid chromatography
- liquid chromatography
- sensitive detection
- solid phase extraction
- single molecule
- label free
- small molecule
- energy transfer
- single cell
- cell free
- nucleic acid
- climate change
- high resolution mass spectrometry
- human health
- risk assessment