Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.
Claudia H T TamCadmon K P LimAndrea O Y LukMai ShiHoi Man CheungAlex C W NgHeung-Man LeeEric S H LauBaoqi FanGuozhi JiangAlice P S KongRisa OzakiElaine Y K ChowKa Fai LeeShing Chung SiuGrace HuiChiu Chi TsangKam Piu LauJenny Y Y LeungElaine Y N CheungMan Wo TsangGrace KamIp Tim LauJune K Y LiVincent T F YeungEmmy LauStanley LoSamuel FungYuk Lun ChengChun Chung ChowXiaodan FanTing Fung ChanKevin Y L YipSi LokWeichuan YuStephen K W TsuiHui-Yao LanCheuk Chun SzetoNelson L S TangBrian TomlinsonYu HuangAlicia J JenkinsAnthony KeechWing-Yee SoJuliana C N ChanRonald Ching-Wan Manull nullPublished in: Diabetes care (2023)
We discovered a novel CHD- and BP-related variant at PDE1A that interacted with BP goal attainment with divergent effects on CHD risk in Chinese patients with T2D. Incorporating this information may facilitate individualized treatment strategies for precision care in diabetes, only when our findings are validated.