Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis.

Vasudevan RamachandranNur Afiqah MohamadMohd Nazil SallehWan Aliaa Wan SulaimanLiyana Najwa Inche MatMohd Hazmi MohamedChing Siew MooiAbdul Hanif Khan Yusof KhanHamidon BasriPannerselvam PeriasamyVajiravelu SuganthiNarenkumar Jayaraman

Published in: Dementia and geriatric cognitive disorders (2024)

Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended.

Keyphrases

copy number
mild cognitive impairment
cognitive decline
current status
south africa
cognitive impairment
genome wide
high fat diet
type diabetes
gene expression
skeletal muscle
insulin resistance