Virtual pacing of a patient's digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy.
Tijmen KoopsenWillem GerritsNick van OstaTim van LoonPhilippe C WoutersFrits W PrinzenKevin VernooyTammo DelhaasArco J TeskeMathias MeineMaarten J CramerJoost LumensPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)
Our results suggest that the reduction of septal-to-lateral work imbalance by virtual pacing in the DT can predict real-world post-CRT LV reverse remodelling. This DT approach could prove to be an additional tool in selecting HF patients for CRT and has the potential to provide valuable insights in optimization of CRT delivery.
Keyphrases
- cardiac resynchronization therapy
- left ventricular
- heart failure
- hypertrophic cardiomyopathy
- end stage renal disease
- ejection fraction
- acute myocardial infarction
- newly diagnosed
- aortic stenosis
- mitral valve
- chronic kidney disease
- left atrial
- prognostic factors
- case report
- acute heart failure
- atrial fibrillation
- risk assessment
- human health
- aortic valve
- acute coronary syndrome
- transcatheter aortic valve replacement