Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways.
Hanan M HassanYasmen F MahranAmal M H GhanimPublished in: The Journal of pharmacy and pharmacology (2022)
GL significantly improved renal function indices through dose-dependent kidney function restoration, oxidative stress reduction, down-regulation of gene expression of KIM-1 and TLR4/NFκB signalling pathway blockage with subsequent alleviation of renal inflammation and fibrosis.
Keyphrases
- oxidative stress
- diabetic nephropathy
- gene expression
- toll like receptor
- nuclear factor
- inflammatory response
- lps induced
- signaling pathway
- immune response
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- dna methylation
- pi k akt
- transcription factor
- transforming growth factor
- mouse model
- liver fibrosis
- epithelial mesenchymal transition
- heat shock