Clinical outcomes of breast leptomeningeal disease treated with intrathecal trastuzumab, intrathecal chemotherapy, or whole brain radiation therapy.
Nicholas B FiguraVictoria T RizkHoman MohammadiBrittany EverndenSepideh MokhtariH Michael YuTimothy J RobinsonArnold B EtameNam D TranJames LiuIman WashingtonRoberto DiazBrian J CzernieckiHatem SolimanHyo S HanSolmaz SahebjamPeter A ForsythKamran A AhmedPublished in: Breast cancer research and treatment (2019)
In our institutional series, significant differences were noted in CS-PFS and OS by treatment modality. IT trastuzumab should be considered in the management HER2+ breast leptomeningeal disease.