Airway injury induces alveolar epithelial and mesenchymal responses mediated by macrophages.

Irene G WongJillian StarkVanNashlee YaAaron L MoyeAlan Baez VazquezSusanna M DangAndrea ShehajMaral J RouhaniRoderick BronsonSam M JanesSamuel P RowbothamMargherita PaschiniRuth A FranklinCarla F Kim

Published in: bioRxiv : the preprint server for biology (2024)

- Alveolar macrophages have a pro-fibrotic effect on lung mesenchyme after airway injury- Damage to one epithelial compartment can elicit altered epithelial-immune-mesenchymal cell crosstalk in another compartment of the same tissue.

Keyphrases

bone marrow
stem cells
oxidative stress
single cell
systemic sclerosis
idiopathic pulmonary fibrosis
anti inflammatory