Rh null phenotype in an Indian patient due to a novel c.1138 + 2 t > a mutation in the RHAG gene.

The novel c.1138+2 t > a mutation in the RHAG gene causing the Rhnull phenotype and development of a pan reacting antibody(ies) made the patient's pregnancy challenging. Confirmation of the diagnosis, an important step in her management, required use of both serological immunohematology and molecular techniques.