C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome.

Danyu YouKun NieXiaoting WuMengjie WengLiyan YangYi ChenJiong CuiJian-Xin Wan

Published in: Journal of translational medicine (2023)

Our data revealed that C3a/C3aR synergies with TGF-β to activate the NLRP3 inflammasome to promote epithelial-mesenchymal transition of renal tubular epithelial cells through ERK signaling, and the way in which C3aR activates the inflammasome is to promote the assembly of the NLRP3 inflammasome.

Keyphrases

nlrp inflammasome
epithelial mesenchymal transition
transforming growth factor
signaling pathway
cell proliferation
pi k akt
electronic health record
high glucose
big data
machine learning
data analysis
artificial intelligence