Novel protein kinase inhibitor TT-00420 inhibits gallbladder cancer by inhibiting JNK/JUN-mediated signaling pathway.

Huijie MiaoYajun GengYang LiShijie TangFeiling FengWeijian LiYongsheng LiLiguo LiuRui ZhangShimei QiuYing WuZeyu WangZiyi WangZiyu ShaoKe LiuLu ZouMao YangYuhao ZhaoChen ChenZhizhen LiDadong ZhangPeng PengXiaoyan QiangFrank WuYongning HeLuonan ChenDongxi XiangXiaoqing JiangMaolan LiYun LiuYing-Bin Liu

Published in: Cellular oncology (Dordrecht) (2022)

TT-00420 shows potent antitumor efficacy and may serve as a novel agent to improve GBC prognosis.

Keyphrases

signaling pathway
protein kinase
pi k akt
induced apoptosis
papillary thyroid
epithelial mesenchymal transition
squamous cell
cell death
lymph node metastasis
childhood cancer
squamous cell carcinoma
oxidative stress
young adults
cell proliferation