The role of platelets and von Willebrand factor in the procoagulant phenotype of inflammatory bowel disease.

Célia SchellenbergJérémy LagrangeMuhammad Usman AhmedDjésia ArnonePhilippe CampoliHuguette LouisNina ToulyBénédicte CaronFrançois PlénatJulien PerrinPeter J LentingVéronique Regnault Patrick LacolleyCécile V DenisLaurent Peyrin-Biroulet

Published in: Journal of Crohn's & colitis (2023)

Platelets and VWF (including its active form) appear to be central players in the procoagulant phenotype in IBD. We observed that the role of VWF in hemostasis differs from its role in colic tissue healing, potentially opening new therapeutic avenues for a life-threatening complication in IBD patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
patient reported outcomes