A combination of immunohistochemical markers, MUC1, MUC5AC, PAX8 and growth pattern for characterization of mucinous neoplasm of the ovary.

Anca Chelariu-RaicuEva HolleyDoris MayrFrederick KlauschenFabienne WehweckMiriam RottmannMirjana KesslerTill KaltofenBastian CzogallaFabian TrillschSven MahnerElisa Schmoeckel

Published in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2022)

The study data support the diagnostic value of MUC1 as a new biomarker to differentiate between primary and metastatic mucinous ovarian cancer. In addition, the tumor growth pattern along with the PAX8 immunophenotype might represent potential prognostic biomarkers for primary mucinous ovarian carcinomas.

Keyphrases

low grade
high grade
squamous cell carcinoma
small cell lung cancer
electronic health record
big data
machine learning
deep learning
artificial intelligence