Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.

Shanti Narayanasamy Roger L NationAndrew A MahonyM Lindsay GraysonJason C KwongNorelle L SherrySharmila KhumraAndrew G EllisAlbert G FraumanNatasha E Holmes

Published in: Open forum infectious diseases (2020)

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.

Keyphrases

drug resistant
acinetobacter baumannii
multidrug resistant
pseudomonas aeruginosa
gram negative
klebsiella pneumoniae
cystic fibrosis
biofilm formation
risk assessment
single cell
emergency department
staphylococcus aureus
urinary tract infection
adverse drug