Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review.
Andrea BrignoliEleonora FerraraMicol ZannettiGianfranco LoiLaura FortiCarlo SocciAlessandro CarrieroAlessandra GennariMarco KrengliPierfrancesco FrancoPublished in: Current oncology (Toronto, Ont.) (2023)
We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management.
Keyphrases
- locally advanced
- rectal cancer
- phase ii study
- computed tomography
- squamous cell carcinoma
- case report
- radiation therapy
- magnetic resonance imaging
- risk assessment
- machine learning
- palliative care
- stem cells
- magnetic resonance
- mesenchymal stem cells
- lymph node
- phase iii
- metastatic colorectal cancer
- open label
- diabetic rats
- early onset
- radiation induced
- cell therapy
- irritable bowel syndrome