Leaky gut and inflammatory biomarkers in a medication overuse headache model in male rats.
Doğa VuralliHale Gök DağidirElif Abbasoğlu TopaHayrunnisa Bolay BelenPublished in: Turkish journal of medical sciences (2023)
Elevated serum occludin and LBP levels and brain IL-17 and HMGB1 levels indicate a possible role of leaky gut and inflammation in an MOH model in male rats. Additionally, a significant correlation between pain behavior and markers of inflammation and intestinal hyperpermeability, supports the role of inflammation and leaky gut in MOH pathophysiology.