Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning.
Kyriaki FountaDimitra DafouEirini KanataTheodoros SklaviadisTheodoros P ZanosAnastasios GounarisKonstantinos XanthopoulosPublished in: Molecular medicine (Cambridge, Mass.) (2023)
Using SES, we addressed the challenge of high dimensionality in gene expression data analysis, and we trained accurate machine learning ALS classifiers, specific for the gene expression patterns of different disease subtypes and tissue samples, while identifying disease-associated genes.