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Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas.

Andrés Cano-GalianoAnais OudinFred FackMaria-Francesca AllegaDavid SumptonElena Martinez-GarciaGunnar DittmarAnn-Christin HauAlfonso De FalcoChristel Herold-MendeRolf BjerkvigJohannes MeiserSaverio TarditoSimone P Niclou
Published in: Neuro-oncology advances (2021)
We show that IDH1-mutant astrocytic gliomas critically rely on NADPH-independent de novo GSH synthesis via CSE to maintain the antioxidant defense, which highlights a novel metabolic vulnerability that may be therapeutically exploited.
Keyphrases
  • wild type
  • oxidative stress
  • low grade
  • anti inflammatory
  • high grade
  • fluorescent probe
  • climate change
  • innate immune
  • living cells
  • reactive oxygen species