Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas.

Andrés Cano-GalianoAnais OudinFred FackMaria-Francesca AllegaDavid SumptonElena Martinez-GarciaGunnar DittmarAnn-Christin HauAlfonso De FalcoChristel Herold-MendeRolf BjerkvigJohannes MeiserSaverio TarditoSimone P Niclou

Published in: Neuro-oncology advances (2021)

We show that IDH1-mutant astrocytic gliomas critically rely on NADPH-independent de novo GSH synthesis via CSE to maintain the antioxidant defense, which highlights a novel metabolic vulnerability that may be therapeutically exploited.

Keyphrases

wild type
oxidative stress
low grade
anti inflammatory
high grade
fluorescent probe
climate change
innate immune
living cells
reactive oxygen species