Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas.
Andrés Cano-GalianoAnais OudinFred FackMaria-Francesca AllegaDavid SumptonElena Martinez-GarciaGunnar DittmarAnn-Christin HauAlfonso De FalcoChristel Herold-MendeRolf BjerkvigJohannes MeiserSaverio TarditoSimone P NiclouPublished in: Neuro-oncology advances (2021)
We show that IDH1-mutant astrocytic gliomas critically rely on NADPH-independent de novo GSH synthesis via CSE to maintain the antioxidant defense, which highlights a novel metabolic vulnerability that may be therapeutically exploited.