Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity.
Eduardo Nunes ChiniGuillermo AgorrodyLaura ColmanSonu KashyapJulianna D ZeidlerClaudia Christiano Silva ChiniGina M WarnerKatie L ThompsonPranjali DalviFelipe Cesar BeckedorffSanam EbtehajJoerg HerrmannWim van SchootenEduardo Nunes ChiniPublished in: Cardiovascular research (2024)
NAD+-preserving strategies by inactivation of CD38 via a genetic or a pharmacological-based approach improve cardiac energetics and reduce cardiac inflammation and dysfunction otherwise seen in an acute DXR cardiotoxicity model.