Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an Italian tertiary cancer center.
Giovanni FucàMara LecchiChiara Maura CiniselliArianna OttiniAndrea SpagnolettiLaura MazzeoDaniele MorelliPaola FratiMartina StrosciaElisabella EbrahemElisa SottotettiGiulia GalliMaria Grazia D'EliaRiccardo LobefaroMonika DucceschiLorenza Di GuardoSherrie BhooriSalvatore ProvenzanoMarco PlataniaMonica NigerElena ColomboFederico NichettiMatteo DucaLicia RivoltiniRoberta MortariniPaolo BailiGiovanni ApoloneFilippo de BraudPaolo VerderioSilvia DamianPublished in: Therapeutic advances in medical oncology (2022)
The systemic immunosuppression characterizing cancer patients did not seem to dramatically affect the humoral response to anti-SARS-CoV-2 mRNA vaccines in our population of patients with solid tumors. Further investigation is needed to dissect the interplay between immunotherapy and longitudinal dynamics of humoral response to mRNA vaccines, as well as to analyze the cellular response to mRNA vaccines in cancer patients.