Zinc oxide nanoparticles produced by Zingiber officinale ameliorates acute toxoplasmosis-induced pathological and biochemical alterations and reduced parasite burden in mice model.
Asmaa M El-KadyAbeer S HassanKhalil MohamedMashael S AlfaifiHayam ElshazlyZaenah Zuhair AlamriMajed H WakidHattan S GattanSarah A AltwaimWafa Abdullah I Al-MegrinSalwa YounisPublished in: PLoS neglected tropical diseases (2023)
The produced formula showed a good therapeutic potential in treatment of murine toxoplasmosis as demonstrated by prolonged survival rate, reduced parasite burden, improved T. gondii associated liver injury and histopathological alterations. Thus, we assume that the protective effect observed in the current research is attributed to the antioxidant capability of NPs. Based on the results obtained from the current work, we suggest greenly produced ZnO NPs as a chemotherapeutic agent with good therapeutic potential and high levels of safety in the treatment of toxoplasmosis.
Keyphrases
- oxide nanoparticles
- drug induced
- liver injury
- toxoplasma gondii
- type diabetes
- metabolic syndrome
- liver failure
- risk factors
- high glucose
- quantum dots
- insulin resistance
- skeletal muscle
- hepatitis b virus
- gold nanoparticles
- life cycle
- human milk
- room temperature
- ionic liquid
- high fat diet induced
- replacement therapy
- endothelial cells
- reduced graphene oxide