Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.

Madeleine JenningBianka MarkleinJimmy YtterbergRoman A ZubarevVijay JoshuaDirkjan van SchaardenburgLotte van de StadtAnca Irinel CatrinaUte NonhoffThomas HäuplZoltán KonthurGerd R BurmesterKarl Skriner

Published in: Annals of the rheumatic diseases (2020)

RACH2007-PPAD induced internal citrullination of major RA autoantigens. Anti-RACH2007-PPAD correlates with ACPA levels and interstitial lung disease autoantigen reactivity, supporting an infection-based concept for induction of ACPAs via enzymatic mimicry.

Keyphrases

interstitial lung disease
systemic sclerosis
rheumatoid arthritis
idiopathic pulmonary fibrosis
high glucose
diabetic rats
oxidative stress
nitric oxide
drug induced
ankylosing spondylitis