Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases.
Toru YoshidaHideaki TsugePublished in: Toxins (2021)
Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this specificity is poorly understood. Here, we review the substrate recognition mechanism and target residue specificity based on the available complex structures of ARTs and their substrates. We show that there are common mechanisms of target residue specificity among protein- and DNA-targeting ARTs.
Keyphrases
- structural basis
- circulating tumor
- amino acid
- single molecule
- cell free
- escherichia coli
- pseudomonas aeruginosa
- staphylococcus aureus
- cancer therapy
- antimicrobial resistance
- protein protein
- binding protein
- nucleic acid
- hiv infected
- biofilm formation
- cystic fibrosis
- antiretroviral therapy
- mass spectrometry
- circulating tumor cells