Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma.
Anders Jensen KolnesKristin Astrid ØysteseDaniel DahlbergJon Berg-JohnsenPitt NiehusmannJens PahnkeJens BollerslevAnders Palmstrøm JørgensenPublished in: Acta neurochirurgica (2020)
Pituitary surgery is safe and transsphenoidal surgery rarely causes new SAI. Relying solely on morning p-cortisol for diagnosing secondary adrenal insufficiency gives false positives and the Short Synacthen Test remains useful. A peak p-cortisol ≥ 320 during (11.6 μg/dl) Short Synacthen Test indicates a sufficient response, while < 309 nmol/l (11.2 μg/dl) indicates secondary adrenal insufficiency.