Role of autoantibodies and blood-brain barrier leakage in cognitive impairment in systemic lupus erythematosus.
John G HanlyAlexandra LeggeLyna KamintskyAlon FriedmanJaveria A HashmiSteven D BeyeaJohn FiskAntonina OmisadeCynthia CalkinTim BardouilleChris BowenKara MathesonMarvin J FritzlerPublished in: Lupus science & medicine (2022)
Extensive BBB leakage alone was associated with cognitive impairment. These findings suggest that BBB leakage is an important contributor to cognitive impairment, regardless of circulating SLE-related autoantibodies.