HLA-B*08 Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti-Carbamylated Protein Antibody-Positive/Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.
Cristina RegueiroDesire Casares-MarfilKarin LundbergRachel KnevelMarialbert Acosta-HerreraLuis Rodriguez-RodriguezRaquel Lopez-MejiasEva Perez-PampinAna Triguero-MartinezLaura NuñoIván Ferraz-AmaroJavier Rodriguez-CarrioRosario Lopez-PedreraMontse Robustillo-VillarinoSantos CastañedaSara Remuzgo-MartinezMercedes AlperiJuan J Alegre-SanchoAlejandro BalsaIsidoro González-AlvaroAntonio MeraBenjamin Fernandez-GutierrezMiguel Angel González-GayLeendert A TrouwCaroline GrönwallLeonid PadyukovJavier MartinAntonio GonzálezPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
These results identify HLA-B*08 carrying Asp-9 as the MHC locus showing the strongest association with anti-CarP+/anti-CCP- RA. This knowledge may help clarify the role of the HLA in susceptibility to specific subsets of RA, by shaping the spectrum of RA autoantibodies.