Association between Y402H, E318D and R102G polymorphisms of complement proteins genes and the response to intravitreal anti-VEGF treatment in patients with neovascular age-related macular degeneration.
Agnieszka Kubicka-TrząskaIzabella Karska-BastaJoanna KobylarzSylwia DziedzinaMarek SanakBożena Romanowska-DixonPublished in: Klinika oczna (2018)
The study showed that the CC rs1061170 CFH genotype may be associated with the age-related macular degeneration. Additionally, the CC rs1061170 CFH genotype may promote a negative response to anti-VEGF treatment, while patients with the TT rs1061170 CFH genotype showed better functional and structural response to anti-VEGF agents.