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Exploring the complex associations among risks of malnutrition, sarcopenia, and frailty in community-dwelling older adults.

Halil Ibrahim CelikFerda KocKübra SiyasalBüsra AyNazlı Bengu IlterOzge Mengi Celik
Published in: European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity (2024)
The SARC-F partially mediates the association between the MNA-SF and the FRAIL, indicating that malnutrition affects frailty through an indirect path via sarcopenia. Furthermore, the PA level moderates this mediator effect, with sarcopenia serving as a mediator in older adults with moderate a PA level but not in those with a low PA level. These findings reveal that it may be beneficial to consider PA level in combination with malnutrition and sarcopenia in the management and prevention of frailty in community-dwelling older adults.
Keyphrases
  • community dwelling
  • skeletal muscle
  • physical activity
  • gene expression
  • single cell
  • dna methylation
  • human health