Exploring the complex associations among risks of malnutrition, sarcopenia, and frailty in community-dwelling older adults.

Halil Ibrahim Celik Ferda Koc Kübra Siyasal Büsra Ay Nazlı Bengu Ilter Ozge Mengi Celik

Published in: European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity (2024)

The SARC-F partially mediates the association between the MNA-SF and the FRAIL, indicating that malnutrition affects frailty through an indirect path via sarcopenia. Furthermore, the PA level moderates this mediator effect, with sarcopenia serving as a mediator in older adults with moderate a PA level but not in those with a low PA level. These findings reveal that it may be beneficial to consider PA level in combination with malnutrition and sarcopenia in the management and prevention of frailty in community-dwelling older adults.

Keyphrases

community dwelling
skeletal muscle
physical activity
gene expression
single cell
dna methylation
human health