Study of arginine metabolism in medication overuse chronic migraine: possible defect in NO synthesis.

Giovanni D'AndreaAntonina GucciardiGiuseppe GiordanoGennaro BussoneAlberta Leon

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)

The elevated levels of ADMA and NMMA, inhibitors of nitric oxide synthase, suggest that the metabolism of arginine may be inhibited with a possible reduction of NO release in the circulation of chronic patients. This suggests that the origin of pain may not be related to the vasodilation of trigeminal vascular system that occurs in episodic migraine patients.

Keyphrases

nitric oxide
end stage renal disease
newly diagnosed
nitric oxide synthase
ejection fraction
prognostic factors
healthcare
emergency department
neuropathic pain
chronic pain
patient reported outcomes
spinal cord
patient reported