Monoclonal Gammopathy of Renal Significance with Deposits of Infrequent Morphology: Two Case Reports of Light and Heavy Chain Deposition Disease with Atypical Presentation and Literature Review.
José Carlos De La Flor MerinoMaribel Monroy-CondoriJacqueline Apaza-ChavezIván Arenas-MoncaleanoFrancisco Javier Diaz CrespoXavier E Guerra-TorresJorge L Morales-MontoyaAna Lerma-VerdejoEdna SandovalDaniel VillaCoca-Mihaela VieruPublished in: Medicines (Basel, Switzerland) (2023)
In this case series, we discuss the clinical, analytical, and histopathological findings of two rare cases of LHCDD. Both patients exhibited IgA monoclonality and were diagnosed with monoclonal gammopathy of undetermined significance (MGUS) by the hematology department at the time of renal biopsy. Treatment with steroids and cytotoxic agents targeting the clone cells responsible for the deposition disease resulted in a favorable renal and hematologic response.