Synaptosomes: new vesicles for neuronal mitochondrial transplantation.
Pasquale PiconeGaetana PorcelliCeleste Caruso BavisottoDomenico NuzzoGiacoma GalizziPier Luigi San BiagioDonatella BuloneMarta Di CarloPublished in: Journal of nanobiotechnology (2021)
Taken together these results suggest that synaptosomes can be a natural vehicle for the delivery of molecules and organelles to neuronal cells. Further, the replacement of affected mitochondria with healthy ones could be a potential therapy for treating neuronal mitochondrial dysfunction-related diseases.