Catalytic Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents.

The inert benzylic C-H bond of π-electron-rich heteroaromatic 2,5-dialkylfuran derivatives was conveniently functionalized with ferrocenyl alcohols as alkylation reagents under catalytic acidic conditions at room temperature, which features chemo- and regiospecificity, mild and metallic catalyst-free conditions, and environmental benignity.