Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy.
Yanina GhiglioneMaría Laura PoloAlejandra UriosteAjantha RhodesAlejandro CzernikierCésar TrifoneMaria Florencia QuirogaAlicia SistoPatricia PattersonHoracio SalomónMaría José RolónSonia Bakkour CocoSharon R LewinGabriela TurkNatalia L LauferPublished in: Open forum infectious diseases (2020)
Elimination of HCV in HIV/HCV-coinfected individuals alters immune function and the transcriptional activity of latently infected cells. This report provides insights into the effects of HCV coinfection in HIV persistence and regards coinfected subjects as a population in which HIV remission might prove to be more challenging.
Keyphrases
- hepatitis c virus
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- hiv positive
- hiv aids
- hiv infected patients
- hiv testing
- gene expression
- transcription factor
- men who have sex with men
- induced apoptosis
- systemic lupus erythematosus
- cell death
- cell cycle arrest
- oxidative stress
- heat shock
- endoplasmic reticulum stress
- pi k akt