Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Kunpeng HuMaria C Perez-MatosJosepmaria ArgemiEduardo Vilar-GomezIrina ShalaurovaEsther BullittLee LandeenGo SugaharaHuiyan DengKaran MathurStephanie TranHuimei CaiHanchang HeYusuf YalcinJoana Vieira BarbosaMeritxell Ventura-CotsKatherine MarxAniket P GadSebastian NiezenSofia Izunza BarbaLay-Hong AngYury V PopovZachary FrickerMichelle LaiMichael CurryNezam AfdhalGyongyi SzaboKenneth J MukamalArun J SanyalJames D OtvosRaza MalikTakeshi SaitoMargery A ConnellyNaga P ChalasaniRamon A BatallerZhenghui Gordon JiangPublished in: Hepatology (Baltimore, Md.) (2021)
Impaired lipoprotein metabolism in AH leads to the accumulation of LP-Z in the circulation, which is hepatotoxic from excessive FC. A Z-index ≤ 0.6 predicts 90-day survival independent from conventional biomarkers for disease prognostication.