Population Pharmacokinetics of Voriconazole in Chinese Patients with Hematopoietic Stem Cell Transplantation.

Chaoyang ChenTing YangXinran LiLingyun MaYaou LiuYing ZhouHanyun RenYi Min Cui

Published in: European journal of drug metabolism and pharmacokinetics (2020)

A population pharmacokinetic model of voriconazole was successfully established in Chinese hematopoietic stem cell transplantation patients. Based on the final model, CYP2C19*2 genotyping coupled with therapeutic drug monitoring seems to be useful to guide voriconazole dosing and to explain subtherapeutic concentrations in clinical practice.

Keyphrases

end stage renal disease
clinical practice
acute myeloid leukemia
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
high throughput
patient reported outcomes
patient reported