N 6 -substituated adenosine analog J4 attenuates anxiety-like behaviors in mice.
Lee PeytonBrandon Emanuel LeónHesham EssaYijuang ChernDoo-Sup ChoiPublished in: Psychopharmacology (2022)
Withdrawal from chronic intermittent ethanol exposure and subsequent behavioral testing 72 h later produces minimal affective-like behavior. J4 treatment did however reduce marble-burying behavior and increased time spent in open arms of the elevated plus maze, suggesting J4 may be useful as a general anxiolytic.