Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects.
Karin WarfvingeDiana N KrauseAida MaddahiJacob C A EdvinssonLars EdvinssonKristian A HaanesPublished in: The journal of headache and pain (2020)
These data reveal significant differences in ER receptor expression between male and female rats. This contrasts to CGRP and PACAP release where we did not observe discernable difference between the sexes. Together, this points to a hypothesis where estrogen could have a modulatory role on the trigeminal neuron function in general rather than on the acute CGRP release mechanisms and vasomotor responses.
Keyphrases
- estrogen receptor
- neuropathic pain
- liver failure
- respiratory failure
- electronic health record
- genome wide
- drug induced
- blood brain barrier
- big data
- single cell
- aortic dissection
- hepatitis b virus
- dna methylation
- single molecule
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- artificial intelligence
- breast cancer cells
- endoplasmic reticulum