ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice.
Ngan NguyenSimin XuTerence Yin Weng LamWupeng LiaoW S Fred WongRuowen GePublished in: Molecular medicine (Cambridge, Mass.) (2022)
Together with our previous report, this work further established ISM1 as an endogenous anti-inflammation protein in the lung, restraining excessive host inflammatory response to LPS-triggered ALI and suppressing post-ALI lung fibrosis likely through suppressing NF-κB activation and pro-inflammatory cytokine/chemokine production.