Specific gut pathobionts escape antibody coating and are enriched during flares in patients with severe Crohn's disease.

Carsten Eriksen Niels Banhos Danneskiold-Samsøe Janne Marie Moll Pernille Neve MyersPi W BondegaardSimone VejrumTine Brodka HansenLisbeth Buus RosholmPhilipp Rausch Kristine Højgaard Allin Tine Jess Karsten Kristiansen John Penders Daisy M A E Jonkers Susanne B Pedersen

Published in: Gut (2024)

Distinct gut bacterial IgG2-coating was demonstrated in patients with severe CD and during disease flares. Co-occurrence of non-coated pathobionts with IgG2-coated bacteria points to an uncontrolled inflammatory condition in severe CD mediated via escape from antibody coating by two gut pathobionts.

Keyphrases

early onset
oxidative stress
drug induced
nk cells
hidradenitis suppurativa