Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study.

Marcos D Machado-FraguaSéverine SabiaAurore FayosseCéline Ben HassenFrank van der HeideMika KivimakiArchana Singh-Manoux

Published in: BMC medicine (2023)

Individuals with metabolically healthy obesity before age 60 had a higher risk of incident dementia over a 27-year follow-up; the excess risk dissipates when metabolic health and obesity are measured after 70 years.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
mild cognitive impairment
cognitive impairment
public health
healthcare
cardiovascular disease
adipose tissue
body mass index
physical activity
risk assessment
health promotion