Conversion of T Follicular Helper Cells to T Follicular Regulatory Cells by Interleukin-2 Through Transcriptional Regulation in Systemic Lupus Erythematosus.

He HaoShingo NakayamadaKaoru YamagataNaoaki OhkuboShigeru IwataYoshino InoueMingzeng ZhangTong ZhangYurie Kanda SatohYu ShanTakashi OtsukaYoshiya Tanaka

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Impaired function of Tfr cells might be attributed to defective IL-2 production. Exogenous IL-2 restores the function of Tfr cells through the conversion of Tfh cells to Tfr cells in patients with SLE. Thus, restoring balance between Tfh and Tfr cells may provide new therapeutic approaches in SLE.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
systemic lupus erythematosus
cell death
transcription factor