Effects of cisplatin-5-fluorouracil combination therapy on oxidative stress, DNA damage, mitochondrial apoptosis, and death receptor signalling in retinal pigment epithelium cells.
Hande GucluZeynep Banu DoğanlarVuslat Pelitli GürlüAltan ÖzalAyten DoganMeryem Aysenur TurhanOguzhan DoganlarPublished in: Cutaneous and ocular toxicology (2018)
Our data proved that PF causes cytotoxicity and genotoxicity, at both the cellular and molecular levels, in ARPE 19 cells following particularly prolonged treatment (48 h). Additionally, our results suggest key molecular signals for prevention strategies that can be developed to reduce the severe side effects of PF chemotherapy.
Keyphrases
- oxidative stress
- induced apoptosis
- cell cycle arrest
- combination therapy
- dna damage
- endoplasmic reticulum stress
- cell death
- diabetic rats
- ischemia reperfusion injury
- signaling pathway
- pi k akt
- single molecule
- dna repair
- electronic health record
- artificial intelligence
- cell proliferation
- radiation therapy
- big data
- early onset
- machine learning
- deep learning
- binding protein