ETS Fight Club on Microsatellite Enhancers.

Published in: Blood cancer discovery (2022)

In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovich et al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1-translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription. See related article by Kodgule, Goldman, Monovich et al., p. 34 (5).

Keyphrases

acute lymphoblastic leukemia
transcription factor
allogeneic hematopoietic stem cell transplantation
papillary thyroid
small molecule
signaling pathway
genetic diversity
squamous cell
high throughput
lymph node metastasis