B 12 -Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms.

Jingjing WeiWen-Hao WuRi WangZhongguang YangFei Sun Wen-Bin Zhang

Published in: ACS macro letters (2018)

We report the robust growth of an entirely protein-based, photo- and thermoresponsive Layer-by-Layer nanofilm using genetically encoded SpyTag/SpyCatcher chemistry. The process was facilitated by AdoB 12 -induced tetramerization of photoreceptor proteins. Protein cargos can be released from the film in a light-dependent manner, showing its potential for therapeutic protein delivery.

Keyphrases

protein protein
amino acid
binding protein
small molecule
room temperature