Safety of Live Immunization in DiGeorge Syndrome: A Retrospective Single-Center Study in Korea, 2005-2021.
Sung Min LimJe Hee ShinJee Yeon BaekJi Young LeeJi-Man KangJong Gyun AhnPublished in: Vaccines (2022)
Live immunization is contraindicated in patients with DiGeorge syndrome (DGS). We retrospectively investigated the occurrence of adverse events after live immunization in patients with DGS in Korea. The data of patients matching the International Classification of Disease-10 code of DGS (D82.1) at Severance Hospital Seoul, Korea, were extracted; patients without genetically diagnosed DGS were excluded. Based on T cell immunity status, the included patients were categorized into group A (CD3 < 500 or CD8 < 200 cells/mm 3 ); group B (CD3 ≥ 500 and CD8 ≥ 200 cells/mm 3 ); or group C (unknown). Among 94 patients, 38 (~40%, group A: 8 [21%]; group B: 30 [79%]) underwent immunological testing and 73 (~80%) received at least one live immunization (measles-mumps-rubella vaccination was most common [66/94, ~70%]). Fifty adverse events (fever [ n = 29], upper respiratory infection [ n = 9], diarrhea [ n = 4], rash [ n = 3], thrombocytopenia [ n = 3], injection site pus [ n = 1], and febrile convulsion [ n = 1]) were observed; 13 (26%) occurred in group A, with no significant difference in incidence between groups A and B. Serious adverse events, including intensive care unit hospitalization or death, or diseases due to vaccine strains were not observed. In this study, live immunization was well tolerated by patients with partial DGS.
Keyphrases
- end stage renal disease
- intensive care unit
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- escherichia coli
- healthcare
- risk assessment
- machine learning
- risk factors
- patient reported outcomes
- deep learning
- signaling pathway
- artificial intelligence
- big data
- patient reported
- adverse drug
- cell death
- nk cells
- clostridium difficile