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Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.

Osama Shiraz ShahAzadeh NasrazadaniJulia FoldiJennifer M AtkinsonCelina G KleerPriscilla F McAuliffeTyler J JohnstonWayne StallaertEdaise M da SilvaPier SelenicaHiginio DopesoFresia ParejaDiana MandelkerBritta WeigeltJorge S Reis-FilhoRohit BhargavaPeter C LucasAdrian V LeeSteffi Oesterreich
Published in: bioRxiv : the preprint server for biology (2024)
MDLC displays both ductal and lobular tumor regions. Our multi-omic profiling approach revealed that these morphologically distinct tumor regions harbor distinct intrinsic subtypes and oncogenic features that may cause prognostic uncertainty and therapeutic dilemma. Thus histopathological/molecular profiling of individual tumor regions may guide clinical decision making and benefit patients with MDLC, particularly in the advanced setting where there is increased reliance on next generation sequencing.
Keyphrases
  • single cell
  • decision making
  • transcription factor
  • single molecule
  • gene expression
  • young adults
  • dna methylation
  • circulating tumor cells