Prevalence and characterization of ATM germline mutations in Chinese BRCA1/2-negative breast cancer patients.
Ziguo YangTao OuyangJinfeng LiTianfeng WangZhaoqing FanTie FanBenyao LinJuan ZhangYuntao XiePublished in: Breast cancer research and treatment (2019)
The prevalence of the ATM mutation is approximately 0.4% in Chinese BRCA1/2-negative breast cancer. ATM mutation carriers are significantly more likely to have a family history of cancer and to develop ER- and/or PR-positive breast cancer or lymph node-positive breast cancer.
Keyphrases
- positive breast cancer
- dna repair
- dna damage
- lymph node
- dna damage response
- risk factors
- breast cancer risk
- papillary thyroid
- neoadjuvant chemotherapy
- squamous cell
- squamous cell carcinoma
- estrogen receptor
- oxidative stress
- sentinel lymph node
- breast cancer cells
- lymph node metastasis
- endoplasmic reticulum
- rectal cancer