Evaluating synergistic effects of metformin and simvastatin on ovarian cancer cells.

Sara Mikhael Abdallah KurdiNathalie Khoueiry-ZgheibRoula TahtouhRihab R Nasr George Hilal

Published in: PloS one (2024)

Our data strongly supports the presence of synergy between MTF and SIM in OC cells. The combination's effect is associated with the dysregulation of genes in the key regulators AMPK and mTOR alongside other interconnected pathways.

Keyphrases

induced apoptosis
cell cycle arrest
genome wide
electronic health record
cell proliferation
transcription factor
big data
endoplasmic reticulum stress
cancer therapy
signaling pathway
gene expression
oxidative stress
machine learning
cell death
dna methylation
protein kinase