CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis.

Ozel CapikFatma SanliAli KurtOnur CeylanIlknur SuerMurat KayaMichael M Ittmann Omer Faruk Karatas

Published in: Prostate cancer and prostatic diseases (2021)

In summary, we found that CASC11 is upregulated in PCa cells and clinical tumor samples in comparison to corresponding controls and revealed that ectopic CASC11 overexpression promotes cellular phenotypes associated with PCa progression through CASC11/miR-145/IGF1R axis.

Keyphrases

cell proliferation
long non coding rna
pi k akt
long noncoding rna
induced apoptosis
cell cycle arrest
transcription factor
growth hormone
endoplasmic reticulum stress
signaling pathway
clinical evaluation