Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension.

Gulsev OzenChabha BenyahiaSalma ManiKamel BoukaisAdam M SilversteinRichard BaylesAndrew C NelsenYves CastierClaire DanelHervé MalLucie H ClappDan LongroisXavier Norel

Published in: British journal of pharmacology (2019)

The PGI2 -mimetics retained maximal bronchodilation in PH Group III patients, whereas bronchodilation induced by EP4 receptor agonists was decreased. Restoration of EP4 receptor expression in airways of PH Group III patients with respiratory diseases could bring additional therapeutic benefit.

Keyphrases

pulmonary hypertension
end stage renal disease
ejection fraction
chronic kidney disease
cystic fibrosis
pulmonary artery
pulmonary arterial hypertension
blood pressure
resistance training
respiratory tract
patient reported